Jump to:  A   |   B   |   C   |   D   |   E   |   F   |   G   |   H   |   I   |   J   |   K   |   L   |   M   |   N   |   O   |   P   |   Q   |   R   |   S   |   T   |   U   |   V   |   W   |   X   |   Y

Gene Changes May Put Childhood Cancer Survivors at Risk

Gene Changes May Put Childhood Cancer Survivors at Risk

MONDAY, April 3, 2017 (HealthDay News) -- Many survivors of childhood cancer have mutations in cancer-associated genes, possibly increasing their risk for cancers later in life, researchers report.

The new study included more than 3,000 people who survived childhood cancer for five years or more. More than 12 percent had changes in one of 156 genes linked to increased risk of cancer, the findings showed.

By age 45, more than one-quarter of the people had developed another cancer, most commonly meningioma (brain tumor), thyroid cancer, breast cancer and non-melanoma skin cancer, according to the study.

The report was scheduled for presentation Monday at an American Association for Cancer Research (AACR) meeting in Washington, D.C. Research presented at medical meetings should be considered preliminary until it is published in a peer-reviewed journal.

"The remarkable advances realized over the past four decades in the treatment and survival of pediatric cancer patients is one of the most notable success stories within the cancer field," co-senior study author Les Robison said in an AACR news release. Robison is chairman of St. Jude Children's Research Hospital's department of epidemiology and cancer control in Memphis, Tenn.

"However, childhood cancer survivors are at increased risk of [additional cancers], largely considered to be therapy-related," he added.

Many types of childhood cancer have cure rates of more than 80 percent, and there are now more than 400,000 long-term survivors of childhood cancer in the United States, Robison noted.

While radiation therapy puts them at risk of developing cancers in such areas as the brain, skin, breast, thyroid and connective tissue, this study shows that genetics independently increase the risk for breast cancer, thyroid cancer and sarcomas, Robison said. Sarcomas are tumors that commonly grow in connective tissue, such as the bones, muscles and tendons.

"Our findings have immediate implications for the growing population of long-term survivors of childhood cancer," he said.

The study authors recommend that people who develop specific types of abnormal tissue growth receive genetic counseling.

Robison said the researchers believe the study findings will lead to personalized treatment recommendations based on genetic profiles for children who are newly diagnosed with cancer.

Study co-lead author Zhaoming Wang said more research is needed to understand the possible links between genetic factors and exposure to cancer treatments. In addition, Wang, also with St. Jude's department of epidemiology and cancer control, suggested that further study is needed to replicate the new findings.

More information

The U.S. National Cancer Institute has more on cancer in children and teens.

SOURCE: American Association for Cancer Research, news release, April 3, 2017

Reviewed Date: --

This content was reviewed by Mid-Atlantic Womens Care, PLC. Please visit their site to find an Mid-Atlantic Womens Care obstetrician.

Find a pediatrician
Helpful Information
Mid-Atlantic Womens's Care
Dermatology
Dr. Julia Burden
Dr. Laura Gifford
Dr. Judith Williams
Endocrinology/Diabetology
Dr. Ayanna Butler-Cephas
Dr. Eric Gyuricsko
Dr. Kent Reifschneider
Dr. Reuben Rohn
Dr. Melissa Russell
Dr. Marta Satin-Smith
Hematology and Oncology
Dr. Wilson File
Dr. Eric Lowe
Dr. William Owen
Dr. Linda Pegram
Dr. Katherine Watson
Dr. Eric Werner
Dr. Gary Woods
Health Tips
Helping Kids Get Over their Fears
How Old Is "Old Enough" for Contacts?
NewsLetters
Fewer People Diagnosed with Thyroid Cancer in U.S.
Diseases & Conditions
About Cancer
Alternative Therapy for Cancer
Anatomy of a Child's Brain
Anatomy of the Endocrine System in Children
Anxiety Disorders in Children
Asthma in Children Index
Becker Muscular Dystrophy (BMD) in Children
Bone Marrow Transplant for Children
Brain Tumors in Children
Causes of Cancer
Chemotherapy for Children: Side Effects
Coping with a Diagnosis of Cancer in Children
Diagnosing Cancer
Ewing Sarcoma in Children
Firearms
Hepatitis B (HBV) in Children
Inflammatory and Infectious Musculoskeletal Disorders
Inflammatory and Infectious Neurological Disorders
Inguinal Hernia in Children
Insect Bites and Children
Kidney Transplantation in Children
Meningitis in Children
Mood Disorders in Children and Adolescents
Myasthenia Gravis (MG) in Children
Nutritional Requirements for a Child With Cancer
Online Resources - Medical Genetics
Osteosarcoma (Osteogenic Sarcoma) in Children
Pediatric Blood Disorders
Posttraumatic Stress Disorder (PTSD) in Children
Preparing the School-Aged Child for Surgery
Schizophrenia in Children
School-Aged Child Nutrition
Skin Cancer in Children
Sports Safety for Children
Superficial Injuries Overview
Television and Children
Thalassemia
The Growing Child: 2-Year-Olds
The Heart
The Kidneys
Treatment for Cancer
Treatment for Skin Cancer in Children
Your Child's Asthma
Your Child's Asthma: Flare-ups

Disclaimer: This information is not intended to substitute or replace the professional medical advice you receive from your child's physician. The content provided on this page is for informational purposes only, and was not designed to diagnose or treat a health problem or disease. Please consult your child's physician with any questions or concerns you may have regarding a medical condition.